Panel Series
Abstract
Background and objectives: Whether light emitting diode (LED) irradiation has effects on "beta-amyloid (A beta) induced apoptosis," a leading hypothesis of the cause of Alzheimer's disease (AD), or not?
Study design/materials and methods: Monolayer cell cultures of PC12 were subjected to A beta or/and LED irradiation at various intensity. Cell apoptosis was confirmed by morphological criteria, DNA fragmentation assay, and FAScan flow cytometer assay.
Results: Treatment of the cells with LED irradiation significantly diminished A beta induced apoptosis within 24 hours.
Conclusions: The LED irradiation, when utilized at power of 0.9 W/m(2) and 60 minutes has significantly diminished A beta induced apoptosis of PC12 cells.
Copyright 2003 Wiley-Liss, Inc.
