This chapter discusses the LED low-level light photomodulation for reversal of photoaging. LED arrays using LILT for photomodulation are useful for collagen stimulation, textural smoothing, and reduction of inflammation. Pilot wound-healing studies show slightly accelerated wound resolution. Cellular rescue from UV damage and other toxic insults has been shown in small studies. Our combined multiyear experience and clinical observations confirm that combinations of thermal nonablative photorejuvenation and nonthermal LED photomodulation have a synergistic effect. LED photomodulation is delivered immediately, subsequent to the thermal-based treatment for its antiinflammatory effects, which may reduce the thermally induced erythema and edema of nonablative treatments. Delivery of LED light immediately pre- and post-thermal injury appears to potentiate the effect, as observed from our clinical experience.